The role of <scp>LTBPs</scp> in <scp>TGF</scp> beta signaling
Daniel B. Rifkin, Nalani Sachan, Karan Singh, Elyse Sauber, George Tellides, Francesco Ramirez
Abstract
The purpose of this review is to discuss the transforming growth factor beta (TGFB) binding proteins (LTBP) with respect to their participation in the activity of TGFB. We first describe pertinent aspects of the biology and cell function of the LTBPs. We then summarize the physiological consequences of LTBP loss in humans and mice. Finally, we consider a number of outstanding questions relating to LTBP function.
Topics & Concepts
BiologyTransforming growth factor betaFunction (biology)Transforming growth factorCell biologySignal transductionBETA (programming language)Computer scienceProgramming languageTGF-β signaling in diseasesGrowth Hormone and Insulin-like Growth FactorsCancer, Hypoxia, and Metabolism