Stereoisomeric Pam<sub>2</sub>CS based TLR2 agonists: synthesis, structural modelling and activity as vaccine adjuvants
Arshpreet Kaur, Sakshi Piplani, Deepender Kaushik, Johnson Fung, Isaac G. Sakala, Yoshikazu Honda‐Okubo, S.K. Mehta, Nikolai Petrovsky, Deepak B. Salunke
Abstract
-stereochemistry at the thio-glycerol lipopeptide core was preferred for maximal TLR2/6 activity, as reflected in Th1 immune deviation, higher antibody levels and enhanced vaccine protection against a lethal influenza challenge.
Topics & Concepts
LipopeptideAdjuvantTLR2ChemistryImmune systemCytokineReceptorBiochemistryBiologyInnate immune systemImmunologyBacteriaGeneticsImmune Response and InflammationInfluenza Virus Research StudiesPneumonia and Respiratory Infections