Rickettsial pathogen inhibits tick cell death through tryptophan metabolite mediated activation of p38 MAP kinase
Prachi Namjoshi, Mustapha Dahmani, Hameeda Sultana, Girish Neelakanta
Abstract
-infected tick cells. Furthermore, treatment with p38 MAPK inhibitor affected bacterial replication, decreased phosphorylated p38 MAPK levels and increased tick cell death. However, XA reversed these effects. Taken together, we provide evidence that rickettsial pathogen modulates arthropod tryptophan and p38 MAPK pathways to inhibit cell death for its survival in ticks.
Topics & Concepts
Anaplasma phagocytophilumBiologyp38 mitogen-activated protein kinasesCell biologyMAPK/ERK pathwayProgrammed cell deathKinaseMicrobiologyBiochemistryImmunologyApoptosisBorrelia burgdorferiAntibodyVector-borne infectious diseasesViral Infections and VectorsMosquito-borne diseases and control