Comparative Genomics Reveals a Remarkable Biosynthetic Potential of the <i>Streptomyces</i> Phylogenetic Lineage Associated with Rugose-Ornamented Spores
Yoon‐Hee Chung, Hiyoung Kim, Chang-Hun Ji, Hyun-Woo Je, Dongho Lee, Sang Hee Shim, Hwang‐Soo Joo, Hahk‐Soo Kang
Abstract
phylogeny, we identified a specific monophyletic lineage associated with the highest BGC abundance. Then, using a combined analysis of comparative genomics and a genetic network, we demonstrated that members of this lineage are genetically and biosynthetically diverse, contain a large number of cryptic BGCs with novel genotypes, and thus would be a good target for metabolite characterization studies.
Topics & Concepts
BiologyPhylogenetic treeGenomeLineage (genetic)StreptomycesSecondary metaboliteComparative genomicsGenomicsGenePhylogeneticsGeneticsStreptomyces albusEvolutionary biologyBacteriaMicrobial Natural Products and BiosynthesisGenomics and Phylogenetic StudiesRNA and protein synthesis mechanisms