Brief communication: Immunohistochemical detection of ACE2 in human salivary gland
Yu Usami, Katsutoshi Hirose, Masashi Okumura, Satoru Toyosawa, Takayoshi Sakai
Abstract
The novel, severe acute respiratory syndrome coronavirus (SARS-CoV-2) was firstly reported in late December of 2019 and subsequently caused a global outbreak. It has been shown that SARS-CoV-2 uses ACE2 (Angiotensin Converting Enzyme 2) as a cellular receptor for host cell entry through the surface unit of SARS-CoV spike glycoprotein. In this brief report, we analyze ACE2 protein expression and localization in human salivary gland, and propose a possible role of saliva in the pathogenesis of Coronavirus disease 2019 (COVID-19).
Topics & Concepts
SalivaPathogenesisSalivary glandCoronavirusImmunohistochemistryAngiotensin-converting enzyme 2GlycoproteinOutbreakReceptorVirologyImmunologyBiologyCoronavirus disease 2019 (COVID-19)MedicineDiseasePathologyInternal medicineMolecular biologyInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesCOVID-19 diagnosis using AI