Research and application of hydrostatic high pressure in tumor vaccines (Review)
Shuai Yan, Kai Liu, Lin Mu, Jianfeng Liu, Wan‐Yee Tang, Bin Liu
Abstract
It is well known that hydrostatic pressure (HP) is a physical parameter that is now regarded as an important variable for life. High hydrostatic pressure (HHP) technology has influenced biological systems for more than 100 years. Food and bioscience researchers have shown great interest in HHP technology over the past few decades. The development of knowledge related to this area can better facilitate the application of HHP in the life sciences. Furthermore, new applications for HHP may come from these current studies, particularly in tumor vaccines. Currently, cancer recurrence and metastasis continue to pose a serious threat to human health. The limited efficacy of conventional treatments has led to the need for breakthroughs in immunotherapy and other related areas. Research into tumor vaccines is providing new insights for cancer treatment. The purpose of this review is to present the main findings reported thus far in the relevant scientific literature, focusing on knowledge related to HHP technology and tumor vaccines, and to demonstrate the potential of applying HHP technology to tumor vaccine development. Contents 1. Introduction 2. High hydrostatic pressure overview 3. Effects of high hydrostatic pressure on cells and biomacromolecules 4. High hydrostatic pressure and tumor vaccines 5. High hydrostatic pressure and immunogenic cell death of tumors 6. High hydrostatic pressure and dendritic cell-based tumor vaccines 7. Tumor vaccines and Annexin A5 8.