Motor training improves coordination and anxiety in symptomatic <i>Mecp2</i> -null mice despite impaired functional connectivity within the motor circuit
Yuanlei Yue, Pan Xu, Zhichao Liu, Xiaoqian Sun, Juntao Su, Hongfei Du, Ling‐Ling Chen, Ryan T. Ash, Stelios M. Smirnakis, Rahul Simha, Linda L. Kusner, Chen Zeng, Hui Lü
Abstract
-null circuit’s firing pattern evolved with improved performance over 2 weeks. Moreover, trained mice became less anxious and lived 20% longer than untrained mice. Because motor deficits and anxiety are core symptoms of RTT, which is not diagnosed until well after symptom onset, these results underscore the benefit of motor learning.
Topics & Concepts
Null (SQL)NeuroscienceAnxietyPhysical medicine and rehabilitationPsychologyMedicineBiologyComputer sciencePsychiatryData miningGenetics and Neurodevelopmental DisordersZebrafish Biomedical Research ApplicationsCongenital heart defects research