Organ-on-chip applications in drug discovery: an end user perspective
Naomi Clapp, Augustin Amour, Wendy C. Rowan, Pelin L. Candarlioglu
Abstract
Organ-on-chip (OoC) systems are in vitro microfluidic models that mimic the microstructures, functions and physiochemical environments of whole living organs more accurately than two-dimensional models. While still in their infancy, OoCs are expected to bring ground-breaking benefits to a myriad of applications, enabling more human-relevant candidate drug efficacy and toxicity studies, and providing greater insights into mechanisms of human disease. Here, we explore a selection of applications of OoC systems. The future directions and scope of implementing OoCs across the drug discovery process are also discussed.
Topics & Concepts
Scope (computer science)Organ-on-a-chipDrug discoveryComputer sciencePerspective (graphical)Mechanism (biology)DrugData scienceComputational biologyNanotechnologyPharmacologyMicrofluidicsBiologyBioinformaticsArtificial intelligenceProgramming languageMaterials scienceEpistemologyPhilosophy3D Printing in Biomedical ResearchInnovative Microfluidic and Catalytic Techniques InnovationNeuroscience and Neural Engineering