Disulfiram as a potent metallo-β-lactamase inhibitor with dual functional mechanisms
Cheng Chen, Ke‐Wu Yang, Linyu Wu, Jiaqi Li, Le-Yun Sun
Abstract
We report a promising NDM-1 inhibitor, disulfiram, which can covalently bind to NDM-1 by forming an S–S bond with the Cys208 residue. Cu(DTC)<sub>2</sub> also inactivated NDM-1 through oxidizing the Zn(<sc>ii</sc>) thiolate site of the enzyme.
Topics & Concepts
DisulfiramChemistryCovalent bondIn vivoOxidizing agentEnzymeResidue (chemistry)MetaboliteStereochemistryBiochemistryOrganic chemistryBiologyBiotechnologyAntibiotic Resistance in BacteriaDrug Transport and Resistance MechanismsArsenic contamination and mitigation