Electrochemical radical reactions of alkyl iodides: a highly efficient, clean, green alternative to tin reagents
Diyuan Li, Tsz‐Kan Ma, Reuben J. Scott, Jonathan D. Wilden
Abstract
An electrochemical 'redox-relay' system has been developed which allows the generation of C-centered radicals. Intermolecular 'tin-like' radical reactions can subsequently be conducted under the most benign of conditions. The yields and efficiency of the processes are competitive and even superior in most cases to comparable conditions with tributyltin hydride. The use of air and electricity as the promotor (instead of a tin or other reagent) combined with the aqueous reaction media make this a clean and 'green' alternative to these classic C-C bond forming processes.
Topics & Concepts
ReagentTinAlkylElectrochemistryChemistryFree-radical reactionCombinatorial chemistryOrganic chemistryRadicalPhysical chemistryElectrodeRadical Photochemical ReactionsOxidative Organic Chemistry ReactionsCatalytic C–H Functionalization Methods