Manganese- and rhenium-catalyzed C–H enaminylation: expedient access to novel indole–purine hybrids with anti-tumor bioactivities
Zhongnan Xu, Yuqing Wang, Yucheng Zheng, Zhixing Huang, Lutz Ackermann, Zhixiong Ruan
Abstract
The C–H enaminylation of novel 6-(1<italic>H</italic>-indol-1-yl)-purines with ketenimines was accomplished by means of aqueous manganese and rhenium catalysis, which sets the stage for the facile synthesis of indole–purine hybrids with anti-tumor bioactivities.
Topics & Concepts
RheniumChemistryIndole testManganeseCatalysisPurine metabolismPurineCombinatorial chemistryStereochemistryOrganic chemistryEnzymeCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsClick Chemistry and Applications