A Bi(OTf)<sub>3</sub>-Promoted Hydrosulfonylation of Alkenes with Sulfonyl Hydrazides: An Approach to Branched Sulfones
Zheng Zhou, Qianqian Liu, Zhibin Huang, Yingsheng Zhao
Abstract
-promoted hydrosulfonylation of alkenes with sulfonyl hydrazides to produce branched sulfones is reported, in which various branched sulfones (>40 examples) have been prepared in moderate to good yields. The gram-scale reaction and synthesis of the experimental inhibitor precursor showed the potential application. A preliminary mechanistic study revealed that double-bond migration to form the α,β-conjugated alkene is crucial for this transformation.
Topics & Concepts
SulfonylChemistryAlkeneConjugated systemDouble bondOrganic chemistryCombinatorial chemistryMedicinal chemistryCatalysisAlkylPolymerSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsOrganoselenium and organotellurium chemistry