Emerging Role of ZBP1 in Z-RNA Sensing, Influenza Virus-Induced Cell Death, and Pulmonary Inflammation
Sharath Basavaraju, Sanchita Mishra, Rashi Jindal, Sannula Kesavardhana
Abstract
. We also discuss the functional importance of ZBP1-RIPK3 signaling in recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other viral infections. Understanding these mechanisms of RNA virus-induced cytopathic and pathogenic inflammatory responses is crucial for targeting pathogenic lung infections and human respiratory illness.
Topics & Concepts
InflammationProgrammed cell deathVirusVirologyInfluenza A virusMedicineBiologyImmunologyApoptosisGeneticsinterferon and immune responsesRNA regulation and diseaseViral Infections and Immunology Research