Catalytic alkene skeletal modification for the construction of fluorinated tertiary stereocenters
Liyin Jiang, Pau Sarró, Wei Jie Teo, Jordi Llop, Marcos G. Suero
Abstract
) bond cleavage. The new process, that takes advantage of a Rh-catalyzed carbyne transfer, relies on a branched-selective fluorination of tertiary allyl cations and is distinguished by a wide scope including natural products and drug molecule derivatives as well as adaptability to radiofluorination.
Topics & Concepts
StereocenterAlkeneCatalysisChemistryStereochemistryCombinatorial chemistryOrganic chemistryEnantioselective synthesisFluorine in Organic ChemistryChemical Synthesis and AnalysisAsymmetric Synthesis and Catalysis