Enantioselective Construction of Si‐Stereogenic Center via Rhodium‐Catalyzed Intermolecular Hydrosilylation of Alkene
Tao He, Li‐Chuan Liu, Wenpeng Ma, Bin Li, Qing‐Wei Zhang, Wei He
Abstract
Catalytic, enantioselective synthesis of stereogenic silicon compounds remains a challenge. Herein, we report a rhodium-catalyzed regio- and enantio-selective intermolecular hydrosilylation of alkene with prochiral dihydrosilane. This new method features a simple catalytic system, mild reaction conditions and a wide functional group tolerance.
Topics & Concepts
StereocenterHydrosilylationEnantioselective synthesisAlkeneRhodiumIntermolecular forceCatalysisChemistryStereochemistryOrganic chemistryMoleculeOrganoboron and organosilicon chemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions