Subinhibitory Concentration of Colistin Promotes the Conjugation Frequencies of <i>Mcr-1-</i> and <i>bla</i> <sub>NDM-5</sub> -Positive Plasmids
Xia Xiao, Fuxin Zeng, Ruichao Li, Yuan Liu, Zhiqiang Wang
Abstract
Antimicrobial resistance (AMR) dissemination is a growing global threat. As a last-resort treatment against multidrug-resistant and extensively drug-resistant Gram-negative bacteria, colistin has been used for prophylactic and therapeutic purposes in veterinary medicine.
Topics & Concepts
ColistinPlasmidEscherichia coliMembrane permeabilityBiologyMicrobiologyBacterial outer membraneEnterobacteriaceaeMCR-1GeneAntimicrobialMembraneGeneticsAntibiotic Resistance in BacteriaPharmaceutical and Antibiotic Environmental ImpactsBacterial Genetics and Biotechnology