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Design and synthesis of anti–inflammatory 1,2,3–triazolylpyrrolobenzodiazepinone derivatives and impact of molecular structure on COX–2 selective targeting

Amit Kumar, Mohammad Sarwar Alam, Hinna Hamid, Vaishali Chugh, Tanvi Tikla, Rajeev Kaul, Abhijeet Dhulap, Sunil Sharma

2022Journal of Molecular Structure22 citationsDOI

Topics & Concepts

ChemistryCelecoxibIn vivoPharmacologyIn silicoEnzymeIn vitroDrug discoveryDrugIC50HeLaStructure–activity relationshipArachidonic acidAnti-inflammatoryBiochemistryStereochemistryMedicineBiotechnologyBiologyGeneClick Chemistry and ApplicationsSynthesis and Biological EvaluationSynthesis of β-Lactam Compounds
Design and synthesis of anti–inflammatory 1,2,3–triazolylpyrrolobenzodiazepinone derivatives and impact of molecular structure on COX–2 selective targeting | Litcius