Phosphine‐Catalyzed Enantioselective (3+2) Annulation of Vinylcyclopropanes with Imines for the Synthesis of Chiral Pyrrolidines
Fuhao Zhang, Xuan Dai, Lei Dai, Wenrui Zheng, Wai‐Lun Chan, Xiaodong Tang, Xumu Zhang, Yixin Lü
Abstract
A phosphine-catalyzed highly enantioselective and diastereoselective (up to 98 % ee and >20 : 1 dr) (3+2) annulation between vinylcyclopropanes and N-tosylaldimines has been developed, which allows facile access to a range of highly functionalized chiral pyrrolidines. Notably, this method makes use of vinylcyclopropanes as a synthon for phosphine-mediated asymmetric annulation reaction, which will offer new opportunities for potential applications of cyclopropanes substrates in phosphine-catalyzed organic transformations.
Topics & Concepts
AnnulationEnantioselective synthesisSynthonPhosphineChemistryCatalysisCombinatorial chemistryOrganocatalysisOrganic chemistryCyclopropane Reaction MechanismsAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization Methods