DRD1 downregulation contributes to mechanical stretch-induced lung endothelial barrier dysfunction
Yan Wang, Yujian Liu, Dun‐Feng Xu, Hui Zhang, Chu‐Fan Xu, Yanfei Mao, Lv Zhou, Xiaoyan Zhu, Lai Jiang
Abstract
This work identifies a novel protective role for DRD1 against mechanical stretch-induced lung endothelial barrier dysfunction and lung injury. Further study of the mechanisms involving DRD1 in the regulation of microtubule stability and interference with DRD1/cAMP/EPAC/HDAC6 signaling may provide insight into therapeutic approaches for VILI.
Topics & Concepts
Downregulation and upregulationLungEndothelial dysfunctionMedicineChemistryCardiologyInternal medicineBiochemistryGeneSpine and Intervertebral Disc Pathology