High Rates of Influenza-Associated Invasive Pulmonary Aspergillosis May Not Be Universal: A Retrospective Cohort Study from Alberta, Canada
Ilan S. Schwartz, Daniel Friedman, Lori Zapernick, Tanis C. Dingle, Nelson Lee, Wendy Sligl, Nathan Zelyas, Stephanie Smith
Abstract
From 2014-2019, invasive pulmonary aspergillosis complicated 7.2% (0-23.1% in different influenza seasons) of cases of influenza-associated respiratory failure in Edmonton, Alberta. Disease outcomes ranged from survival without therapy to death despite antifungals. Clinician vigilance, longitudinal local surveillance, and refined criteria to identify patients requiring therapy are needed.
Topics & Concepts
MedicineAspergillosisRetrospective cohort studyIntensive care medicineRespiratory diseaseCohortPulmonary aspergillosisCohort studyInternal medicineImmunologyLungAntifungal resistance and susceptibilityFungal Infections and StudiesRespiratory and Cough-Related Research