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Design and synthesis of new 1,6-dihydropyrimidin-2-thio derivatives targeting VEGFR-2: Molecular docking and antiproliferative evaluation

Adel A. Marzouk, Salah A. Abdel‐Aziz, Kamal Abdelrahman, Amira S. Wanas, Ahmed M. Gouda, Bahaa G. M. Youssif, Mohamed Abdel‐Aziz

2020Bioorganic Chemistry60 citationsDOI

Topics & Concepts

SorafenibChemistryDocking (animal)In vitroIC50StereochemistryCell cultureThio-Cancer researchBiochemistryBiologyGeneticsHepatocellular carcinomaNursingMedicineSynthesis and biological activityCancer Mechanisms and TherapyPI3K/AKT/mTOR signaling in cancer
Design and synthesis of new 1,6-dihydropyrimidin-2-thio derivatives targeting VEGFR-2: Molecular docking and antiproliferative evaluation | Litcius