Self-catalyzed tumor ferroptosis based on ferrocene conjugated reactive oxygen species generation and a responsive polymer
Jisi Li, Qingyu Zong, Ye Liu, Xuan Xiao, Jielian Zhou, Zhongyi Zhao, Youyong Yuan
Abstract
In this work, we developed a ferroptosis self-catalyst, PTAF, exhibiting self-catalyzed ferroptosis for enhanced cancer therapy. Briefly, synergistic actions of self-catalyzed ˙OH accumulation and GPX4 indirect inactivation based on the establishment of the ROS self-catalytic loop effectively induced tumor ferroptosis, which provided a novel approach for enhanced tumor therapy.
Topics & Concepts
CatalysisReactive oxygen speciesConjugated systemFerroceneChemistryOxygenPolymerCombinatorial chemistryPhotochemistryBiochemistryOrganic chemistryElectrodePhysical chemistryElectrochemistryNanoplatforms for cancer theranosticsFerroptosis and cancer prognosisRNA modifications and cancer