Elucidation of Structure–Activity Relationships in Indolobenzazepine-Derived Ligands and Their Copper(II) Complexes: the Role of Key Structural Components and Insight into the Mechanism of Action
Irina Kuznetcova, Felix Bacher, Samah Mutasim Alfadul, Max Jing Rui Tham, Wee Han Ang, Maria V. Babak, Peter Rapta, Vladimir B. Arion
Abstract
was linked to reactive oxygen species and endoplasmic reticulum stress induction, which were confirmed by fluorescent microscopy and Western blot analysis.
Topics & Concepts
ChemistryElectrospray ionizationStereochemistryMass spectrometryBenzazepinesNuclear magnetic resonance spectroscopyProton NMRCarbon-13 NMRChromatographySynthesis and bioactivity of alkaloidsSynthesis and Biological EvaluationMulticomponent Synthesis of Heterocycles