A randomised phase 2 study of intermittent versus continuous dosing of dabrafenib plus trametinib in patients with BRAFV600 mutant advanced melanoma (INTERIM)
Alimu Dayimu, Avinash Gupta, Rubeta Matin, Jenny Nobes, Ruth Board, Miranda Payne, Ankit Rao, Alberto Fusi, Sarah Danson, Bryony Eccles, Judith Carser, Ciara O’Hanlon Brown, Neil Steven, Madhumita Bhattacharyya, Ewan Brown, Michael Gonzalez, Martin Highley, Lisa Pickering, Satish Kumar, Ashita Waterston, George J. Burghel, Leigh Demain, Eleanor Baker, Jerome Wulff, Wendi Qian, Sophie Twelves, Mark R. Middleton, Pippa Corrie
Topics & Concepts
DabrafenibMedicineTrametinibDosingInterim analysisInternal medicineClinical endpointAdverse effectMelanomaRegimenProgression-free survivalDiscontinuationQuality of life (healthcare)OncologyGastroenterologySurgeryRandomized controlled trialChemotherapyCancerVemurafenibBiologyMetastatic melanomaKinaseCancer researchCell biologyNursingMAPK/ERK pathwayMelanoma and MAPK PathwaysCutaneous Melanoma Detection and ManagementLung Cancer Treatments and Mutations