Plant-Derived Natural Non-Nucleoside Analog Inhibitors (NNAIs) against <i>RNA-Dependent RNA Polymerase</i> Complex (nsp7/nsp8/nsp12) of SARS-CoV-2
Sreus A. G. Naidu, Ghulam Mustafa, Roger Clemens, A. Satyanarayan Naidu
Abstract
(pyrrolidine alkaloid), with superior redox characteristics (free binding energy, hydrogen-bonds, etc.) than antiviral drugs (i.e. remdesivir, favipiravir). These phytonutrient-NNAIs also exert anti-inflammatory, antioxidant, immunomodulatory and cardioprotective functions, with multifunctional therapeutic benefits in the clinical management of COVID-19.
Topics & Concepts
RNA-dependent RNA polymeraseChemistryBiochemistryPolymeraseDruggabilityBiologyRNA polymeraseRNAEnzymeGeneComputational Drug Discovery MethodsSARS-CoV-2 and COVID-19 ResearchCRISPR and Genetic Engineering