Impact of antimicrobial peptides on <i>E. coli</i>-mimicking lipid model membranes: correlating structural and dynamic effects using scattering methods
Josefine Eilsø Nielsen, Sylvain Prévost, Håvard Jenssen, Reidar Lund
Abstract
. We compare these results with earlier published data on model systems based on PC-lipids (phosphatidylcholines), showing comparable effect with regards to peptide insertion and effect on dynamics. However, model systems based on PE-lipids (phosphatidylethanolamine) are more prone to destabilisation upon addition of peptides, with formation of multilamellar structures and morphological changes. These properties of PE-vesicles lead to less conclusive results regarding peptide effect on structure and dynamics of the membrane.
Topics & Concepts
Antimicrobial peptidesMagaininChemistryPhosphatidylethanolamineVesicleMembraneLipid bilayerPeptideColistinPhospholipidPhosphatidylcholineSmall-angle X-ray scatteringBiophysicsLiposomeBilayerSmall-angle neutron scatteringAntimicrobialNeutron scatteringBiochemistryScatteringBiologyOrganic chemistryPhysicsOpticsAntimicrobial Peptides and ActivitiesLipid Membrane Structure and BehaviorImmune Response and Inflammation