Functional CRISPR dissection of gene networks controlling human regulatory T cell identity
Kathrin Schumann, Siddharth S. Raju, Michael Lauber, Saskia Kolb, Eric Shifrut, Jessica T. Cortez, Nikolaos Skartsis, Vinh Nguyen, Jonathan M. Woo, Theodore L. Roth, Ruby Yu, Michelle Nguyen, Dimitre R. Simeonov, David N. Nguyen, Sasha Targ, Rachel E. Gate, Qizhi Tang, Jeffrey A. Bluestone, Matthew H. Spitzer, Chun Ye, Alexander Marson
Topics & Concepts
BiologyTranscription factorGene regulatory networkFOXP3GeneIRF4Regulation of gene expressionCRISPRCell biologyGeneticsComputational biologyImmune systemGene expressionT-cell and B-cell ImmunologyImmune Cell Function and InteractionSingle-cell and spatial transcriptomics