BEST4<sup>+</sup> cells in the intestinal epithelium
Tania Malonga, Nathalie Vialaneix, Martín Beaumont
Abstract
BEST4 + cells are a novel subtype of mature absorptive cells in the human intestinal epithelium highlighted by single-cell transcriptomics. The gene expression profile of BEST4 + cells suggests their role in pH regulation, electrolyte secretion, mucus hydration, and innate immune defense. The absence of BEST4 + cells in mice requires the use of alternative animal models or organoids to decipher the role of this novel type of intestinal epithelial cells.
Topics & Concepts
EpitheliumIntestinal epitheliumBiologyChemistryPhysicsGeneticsSingle-cell and spatial transcriptomicsCell Adhesion Molecules ResearchBarrier Structure and Function Studies