Selenoprotein S maintains intestinal homeostasis in ulcerative colitis by inhibiting necroptosis of colonic epithelial cells through modulation of macrophage polarization
Yujie Yao, Tong Xu, Xiaojing Li, Xu Shi, Hao Wu, Ziwei Zhang, Shiwen Xu
Abstract
SelS is required for maintaining intestinal homeostasis and that its deletion enhances necroptosis in CECs, which is further exacerbated by promoting M1 macrophage polarization, and triggers more severe barrier dysfunction and inflammatory responses in UC.
Topics & Concepts
NecroptosisMacrophage polarizationUlcerative colitisColitisHomeostasisChemistryMacrophageCell biologyMedicinePathologyImmunologyBiologyApoptosisProgrammed cell deathBiochemistryIn vitroDiseaseSelenium in Biological Systems