MTDH antisense oligonucleotides reshape the immunosuppressive tumor microenvironment to sensitize Hepatocellular Carcinoma to immune checkpoint blockade therapy
Jing-Lei Wan, Biao Wang, Mei-Lan Wu, Jie Li, Ruo-Mu Gong, Lina Song, Hanshuo Zhang, Gui‐Qi Zhu, Shiping Chen, Jialiang Cai, Xiaoxia Xing, Yadong Wang, Yi Yang, Cheng-Zhe Cai, Run Huang, Hua Liu, Zhi Dai
Topics & Concepts
Cancer researchImmune checkpointImmune systemTumor microenvironmentPD-L1Downregulation and upregulationChromatin immunoprecipitationImmunotherapyBiologyImmunologyPromoterGene expressionBiochemistryGeneCancer Mechanisms and TherapyPeptidase Inhibition and Analysis