Ruthenium(<scp>ii</scp>)-catalyzed oxidative dehydrogenation and hydroarylation of maleimides with phthalazinones – insights into additive-controlled product selectivity
Alagumalai Ramkumar, Ramdas Sreedharan, Purushothaman Rajeshwaran, Thirumanavelan Gandhi
Abstract
Herein, we developed ruthenium(II)-catalyzed oxidative dehydrogenation and hydroarylation of maleimides with phthalazinones. The product selectivity is controlled by the additives, and the hydroarylated product was obtained in water, which is an important highlight of this study. Control experiments were conducted to elucidate a plausible mechanism. These experiments suggest the occurrence of an oxidative dehydrogenation pathway over E2-type elimination - the key step in producing Heck-type products.
Topics & Concepts
ChemistryDehydrogenationSelectivityRutheniumCatalysisOxidative phosphorylationProduct (mathematics)Organic chemistryCombinatorial chemistryBiochemistryGeometryMathematicsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisNanomaterials for catalytic reactions