X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system
Martin W. LaFleur, Ashlyn M. Lemmen, Ivy S. L. Streeter, Thao H. Nguyen, Lauren E. Milling, Nicole M. Derosia, Zachary M. Hoffman, Jacob E. Gillis, Qin Tjokrosurjo, Samuel C. Markson, Amy Y. Huang, Praju Vikas Anekal, Paula Montero Llopis, W. Nicholas Haining, John G. Doench, Arlene H. Sharpe
Topics & Concepts
Lineage (genetic)GeneBiologyComputational biologyImmune systemGeneticsCRISPR and Genetic Engineeringinterferon and immune responsesCAR-T cell therapy research