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X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system

Martin W. LaFleur, Ashlyn M. Lemmen, Ivy S. L. Streeter, Thao H. Nguyen, Lauren E. Milling, Nicole M. Derosia, Zachary M. Hoffman, Jacob E. Gillis, Qin Tjokrosurjo, Samuel C. Markson, Amy Y. Huang, Praju Vikas Anekal, Paula Montero Llopis, W. Nicholas Haining, John G. Doench, Arlene H. Sharpe

2023Nature Immunology13 citationsDOIOpen Access PDF

Topics & Concepts

Lineage (genetic)GeneBiologyComputational biologyImmune systemGeneticsCRISPR and Genetic Engineeringinterferon and immune responsesCAR-T cell therapy research
X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system | Litcius