Host–guest interaction-based supramolecular prodrug self-assemblies for GSH-consumption augmented chemotherapy
Yang Bai, Xihua Li, Muqiong Li, Qingqing Shang, Jing Yang, Fan Li, Wei Tian
Abstract
The chemotherapy is perplexed by the unsatisfied efficacy due to the GSH-induced detoxification. The SPSAs reported in this study could not only consume GSH but also reduce GSH biosynthesis pathway, paving a novel way to enhance therapeutic efficacy.
Topics & Concepts
Supramolecular chemistryProdrugGlutathioneChemotherapyHost (biology)Materials scienceChemistryOrganic chemistryMoleculeMedicineBiochemistryInternal medicineEcologyBiologyEnzymeSupramolecular Self-Assembly in MaterialsNanoplatforms for cancer theranosticsSupramolecular Chemistry and Complexes