Gut Microbiome in Inflammatory Bowel Disease: Role in Pathogenesis, Dietary Modulation, and Colitis-Associated Colon Cancer
John Gubatan, Theresa Louise Boye, Michelle Temby, Raoul S. Sojwal, Derek Holman, Sidhartha R. Sinha, Stephan Rogalla, Ole Haagen Nielsen
Abstract
The gut microbiome has increasingly been recognized as a critical and central factor in inflammatory bowel disease (IBD). Here, we review specific microorganisms that have been suggested to play a role in the pathogenesis of IBD and the current state of fecal microbial transplants as a therapeutic strategy in IBD. We discuss specific nutritional and dietary interventions in IBD and their effects on gut microbiota composition. Finally, we examine the role and mechanisms of the gut microbiome in mediating colitis-associated colon cancer.
Topics & Concepts
MicrobiomeInflammatory bowel diseasePathogenesisGut microbiomeColorectal cancerGut floraDiseaseColitisImmunologyMedicineCancerUlcerative colitisInflammatory Bowel DiseasesBiologyBioinformaticsInternal medicineGut microbiota and healthClostridium difficile and Clostridium perfringens researchInflammatory Bowel Disease