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Pyruvic acid or DBU/O<sub>2</sub> guided organophotoredox-catalyzed direct C–H alkylation/α-aminoalkylation of 1,2,4-triazine-3,5(2<i>H</i>,4<i>H</i>)-diones with amines

Zhaonan Cai, Xiaohui Cao, Hong‐Yu Zhang, Yuecheng Zhang, Jiquan Zhao

2024Organic Chemistry Frontiers12 citationsDOI

Abstract

Herein, we present an organophotoredox-catalyzed direct C–H alkylation/α-aminoalkylation of 1,2,4-triazine-3,5(2 H ,4 H )-diones with amines in the presence of different additives. In addition, reaction mechanism were further revealed via DFT studies.

Topics & Concepts

ChemistryAlkylationTriazineCatalysisMedicinal chemistryOrganic chemistryFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsRadical Photochemical Reactions
Pyruvic acid or DBU/O<sub>2</sub> guided organophotoredox-catalyzed direct C–H alkylation/α-aminoalkylation of 1,2,4-triazine-3,5(2<i>H</i>,4<i>H</i>)-diones with amines | Litcius