Multipotent RAG1+ progenitors emerge directly from haemogenic endothelium in human pluripotent stem cell-derived haematopoietic organoids
Ali Motazedian, Freya Bruveris, Santhosh V. Kumar, Jacqueline V. Schiesser, Tyrone Chen, Elizabeth Ng, Ann P. Chidgey, Christine A. Wells, Andrew G. Elefanty, Edouard G. Stanley
Topics & Concepts
BiologyCell biologyHaematopoiesisStem cellInduced pluripotent stem cellProgenitor cellRecombination-activating geneCD34Endothelial stem cellCellular differentiationImmunologyEmbryonic stem cellGeneticsIn vitroGeneRecombinationZebrafish Biomedical Research ApplicationsSingle-cell and spatial transcriptomicsImmune cells in cancer