Discovery of novel CA-4 analogs as dual inhibitors of tubulin polymerization and PD-1/PD-L1 interaction for cancer treatment
Xuchao Yang, Binbin Cheng, Yao Xiao, Mingming Xue, Ting Liu, Hao Cao, Jianjun Chen
Topics & Concepts
ChemistryIn vivoTubulinMicrotubule polymerizationCardiotoxicityPharmacologyMicrotubulePolymerizationApoptosisCancer cellIn vitroCancerToxicityBiochemistryCell biologyBiologyPolymerInternal medicineMedicineBiotechnologyOrganic chemistryCAR-T cell therapy researchMelanoma and MAPK PathwaysCancer Immunotherapy and Biomarkers