NIR Spectroscopy as an Online PAT Tool for a Narrow Therapeutic Index Drug: Toward a Platform Approach Across Lab and Pilot Scales for Development of a Powder Blending Monitoring Method and Endpoint Determination
Sameer Talwar, Pallavi Pawar, Huiquan Wu, Koushik Sowrirajan, Suyang Wu, Benoît Igne, Richard J. Friedman, Fernando J. Muzzio, James K. Drennen
Topics & Concepts
Process analytical technologyPrincipal component analysisChemometricsBiological systemHomogeneity (statistics)Near-infrared spectroscopyComputer scienceCalibrationProcess engineeringAlgorithmMaterials scienceData miningMathematicsStatisticsArtificial intelligenceMachine learningEngineeringOpticsWork in processOperations managementPhysicsBiologySpectroscopy and Chemometric AnalysesSpectroscopy Techniques in Biomedical and Chemical ResearchAnalytical Chemistry and Chromatography