Dihydroartemisinin inhibits histone lactylation through YAP1 to act as a ‘hot’ switch for ‘cold’ tumor in hepatocellular carcinoma
Yuting Gao, Yi Gong, Xiaoyong Song, Yajun Xiong, Junlan Lu, Yanguang Yang, Yanli Gong, Zhimin Du, Shanshan Wang, Ru Jia, Peng Gong, Xinli Shi
Topics & Concepts
DihydroartemisininHepatocellular carcinomaCancer researchChemistryHistoneYAP1Tumor microenvironmentImmune systemHistone deacetylasePharmacologyHistone H3Tumor cellsHepatic carcinomaPD-L1CarcinomaImmunotherapyHippo pathway signaling and YAP/TAZHistone Deacetylase Inhibitors ResearchProtein Degradation and Inhibitors