Chromothripsis followed by circular recombination drives oncogene amplification in human cancer
Carolina Rosswog, Christoph Bartenhagen, Anne Welte, Yvonne Kahlert, Nadine Hemstedt, Witali Lorenz, Maria Cartolano, Sandra Ackermann, Sven Perner, Wenzel Vogel, Janine Altmüller, Peter Nürnberg, Falk Hertwig, Gudrun Göhring, Esther Lilienweiss, Adrian M. Stütz, Jan O. Korbel, Roman K. Thomas, Martin Peifer, Matthias Fischer
Topics & Concepts
Extrachromosomal DNAChromothripsisBiologyAmpliconGene duplicationGeneticsOncogeneGenomeHomologous recombinationNon-allelic homologous recombinationCancerDNAMolecular biologyRecombinationGeneGenome instabilityDNA damagePolymerase chain reactionCell cycleGenetic recombinationCancer Genomics and DiagnosticsMicrotubule and mitosis dynamicsNeuroblastoma Research and Treatments