Diffusion along the perivascular space as a potential biomarker for glioma grading and isocitrate dehydrogenase 1 mutation status prediction
Hongquan Zhu, Yan Xie, Li Li, Yufei Liu, Shihui Li, Nanxi Shen, Jiaxuan Zhang, Su Yan, Dong Liu, Yuanhao Li, Wenzhen Zhu
Abstract
Background: ) genotype and to then compare the ALPS index with other diffusion metrics. Methods: status was compared after age adjustment. The diagnostic performance of each metric was assessed via receiver operating characteristic (ROC) analysis. Results: mutation prediction, this combination had the highest AUC of 0.861 as compared to that of 0.707-0.778 for a single metric. Conclusions: genotyping.
Topics & Concepts
Isocitrate dehydrogenaseGliomaDiffusion MRIIDH1Fractional anisotropyNuclear medicineMagnetic resonance imagingMedicinePathologyNuclear magnetic resonanceBiologyRadiologyMutantCancer researchPhysicsBiochemistryEnzymeGeneCerebrospinal fluid and hydrocephalusAdvanced Neuroimaging Techniques and ApplicationsSpinal Dysraphism and Malformations