Hepatic Scaling Factors for In Vitro–In Vivo Extrapolation of Metabolic Drug Clearance in Patients with Colorectal Cancer with Liver Metastasis
Areti‐Maria Vasilogianni, Brahim Achour, Daniel Scotcher, Sheila Annie Peters, Zubida M. Al‐Majdoub, Jill Barber, Amin Rostami‐Hodjegan
Topics & Concepts
Physiologically based pharmacokinetic modellingMicrosomeIn vivoPopulationPharmacokineticsPharmacologyCancerMetastasisInternal medicineChemistryIn vitroBiologyEndocrinologyMedicineBiochemistryEnvironmental healthBiotechnologyPharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsStatistical Methods in Clinical Trials