Gliadin-reactive vitamin D-sensitive proinflammatory ILCPs are enriched in celiac patients
Giuseppe Ercolano, Alex Moretti, Maryline Falquet, Tania Wyss, Ngoc Lan Tran, Isis Senoner, Maddalena Marinoni, Massimo Agosti, Silvia Salvatore, Camilla Jandus, Sara Trabanelli
Abstract
T lymphocytes. IFN-γ is also produced upon stimulation with IL-12p40 and IL-18 and is inhibited by the addition of vitamin D. Low levels of blood vitamin D correlate with high IFN-γ and ILCP presence and mark the CD population mostly affected by extraintestinal symptoms. Dietary vitamin D supplementation appears to be an interesting therapeutic approach to dampen ILCP-mediated IFN-γ production.
Topics & Concepts
Vitamin D and neurologyTissue transglutaminaseProinflammatory cytokineImmunologyGliadinPopulationCytokineInnate lymphoid cellStimulationVitaminInflammationBiologyChemistryEndocrinologyMedicineInnate immune systemGlutenImmune systemBiochemistryEnzymeEnvironmental healthIL-33, ST2, and ILC PathwaysEosinophilic EsophagitisMicroscopic Colitis