Yeast Cell wall Particle mediated Nanotube-RNA delivery system loaded with miR365 Antagomir for Post-traumatic Osteoarthritis Therapy via Oral Route
Long Zhang, Peng Hang, Wan Zhang, Yankun Li, Liang Liu, Tongtong Leng
Abstract
Here, we constructed a biodegradable drug delivery system based on non-pathogenic YCWP and nanotubes, which can be used for PTOA therapy via the oral route. It suggests a new gene therapy strategy with YCWP mediated oral nano drug delivery system may serve as a platform for joint degeneration treatment.
Topics & Concepts
OsteoarthritisAntagomirChondrogenesisDrug deliveryGenetic enhancementMedicineCartilagemicroRNACancer researchChemistryMaterials scienceGenePathologyNanotechnologyBiochemistryAnatomyAlternative medicineOsteoarthritis Treatment and MechanismsRNA Interference and Gene DeliveryKnee injuries and reconstruction techniques