Targeting ER stress and calpain activation to reverse age-dependent mitochondrial damage in the heart
Jeremy Thompson, Michael Maceyka, Qun Chen
Topics & Concepts
Mitochondrial permeability transition poreCalpainMitochondrionOxidative stressReactive oxygen speciesUnfolded protein responseIschemiaEndoplasmic reticulumReperfusion injuryMitochondrial ROSCell biologyMedicineCardiac function curvePharmacologyEndocrinologyChemistryInternal medicineBiologyApoptosisBiochemistryProgrammed cell deathHeart failureEnzymeEndoplasmic Reticulum Stress and DiseaseMitochondrial Function and PathologyCalpain Protease Function and Regulation