ADAR1p150 prevents MDA5 and PKR activation via distinct mechanisms to avert fatal autoinflammation
Shi-Bin Hu, Jacki Heraud-Farlow, Tao Sun, Zhen Liang, Ankita Goradia, Scott Taylor, Carl R. Walkley, Jin Billy Li
Topics & Concepts
MDA5RNA silencingBiologyProtein kinase RRNAInnate immune systemCell biologyEffectorGene isoformEIF-2 kinaseRNA editingRNA-binding proteinImmune systemBiochemistrySignal transductionRNA interferenceGeneticsKinaseGeneProtein kinase ACyclin-dependent kinase 2Protein kinase CMitogen-activated protein kinase kinaseRNA regulation and diseaseRNA Research and Splicinginterferon and immune responses