Palladium-catalyzed [6 + 4] cycloaddition with π-allyl all-carbon 1,6-dipole for the synthesis of ten-membered heterocycles
Juntao Chen, Na Lin, Linli Xu, Yi Wang, Xiaoyan Luo, Yang‐Zi Liu, Wei‐Ping Deng
Abstract
This work introduces a novel α,α-diester-δ-vinylvalerolactone as a dipolar precursor in a palladium-catalyzed [6 + 4] cycloaddition reaction with azadienes, resulting in the production of ten-membered heterocycles.
Topics & Concepts
ChemistryCycloadditionPalladiumCatalysis1,3-Dipolar cycloadditionOrganic chemistryMedicinal chemistryCombinatorial chemistryCatalytic Alkyne ReactionsCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods