Design, synthesis and evaluation of heteroaryldihydropyrimidine analogues bearing spiro ring as hepatitis B virus capsid protein inhibitors
Yue Ma, Shujie Zhao, Yujie Ren, Srinivasulu Cherukupalli, Qilan Li, Molly E. Woodson, Daniel P. Bradley, John E. Tavis, Xinyong Liu, Peng Zhan
Topics & Concepts
ChemistryADMELead compoundIn vivoStereochemistryEC50MorpholineBioavailabilityDocking (animal)CytotoxicityHydrogen bondCapsidIn vitroLipinski's rule of fiveCombinatorial chemistryMoleculePharmacologyBiochemistryOrganic chemistryIn silicoGeneNursingMedicineBiotechnologyBiologyHepatitis B Virus StudiesHepatitis C virus researchHIV/AIDS drug development and treatment