Nickel-Catalyzed Direct Cross-Coupling of Unactivated Aryl Fluorides with Aryl Bromides
Jing‐Ao Ren, Jin-He Na, Chao Gui, Chengping Miao, Xue‐Qiang Chu, Mengtao Ma, Hao Xu, Xiaocong Zhou, Zhi‐Liang Shen
Abstract
A nickel-catalyzed direct cross-coupling of unactivated aryl fluorides with aryl bromides is realized. The one-pot reaction, which avoids the use of preformed and sensitive organometallic reagents, proceeds effectively via C-F bond cleavage at room temperature in THF in the presence of the phosphine ligand and magnesium powder (with or without TMSCl) to produce the desired biaryls in modest to good yields.
Topics & Concepts
ChemistryArylReagentPhosphineNickelCatalysisMagnesiumCombinatorial chemistryCleavage (geology)Ligand (biochemistry)Bond cleavageOrganic chemistryAlkylBiochemistryReceptorGeotechnical engineeringEngineeringFracture (geology)Fluorine in Organic ChemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions