Sensitization of ovarian tumor to immune checkpoint blockade by boosting senescence-associated secretory phenotype
Hao Xue, Bo Zhao, Wei Zhou, Heng Liu, Takeshi Fukumoto, Dmitry I. Gabrilovich, Rugang Zhang
Abstract
T cells and dendritic cells in the tumor bed. Our findings indicate that adoptive transfer of SASP-boosted therapy-induced senescent cells represents a potential therapeutic strategy to sensitize tumors to ICB.
Topics & Concepts
Adoptive cell transferImmune checkpointCancer researchCisplatinImmune systemCD8Ovarian cancerSenescenceMedicineImmunotherapyImmunologyCancerT cellChemotherapyInternal medicineImmunotherapy and Immune ResponsesCancer therapeutics and mechanismsCytomegalovirus and herpesvirus research